Publications

Click here for a full list of Holinstat published papers!

2025 Publications:

Antiplatelet Effects of DMPC-Based Synthetic High-Density Lipoproteins: Exploring Particle Structure and Noncholesterol Efflux Mechanisms.
Protection of β2GPI-Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation.
Cardiovascular disease risk factors in the Native American population.

2024 Publications:

Observational analyses of ex vivo Native American platelet responses.
Clot accumulation in 3D microfluidic bifurcating microvasculature network.
An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis.
Composition of thrombi in zebrafish: similarities and distinctions with mammals.

2023 Publications:

Antiplatelet strategies: past, present, and future.
DAPT and GPVI: an antiplatelet triple threat
Investigating the catalytic efficiency of C22-Fatty acids with LOX human isozymes and the platelet response of the C22-oxylipin products
Protection of β2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation
Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets
The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor
Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors
Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes
Ribosomal protein control of hematopoietic stem cell transformation through direct, non-canonical regulation of metabolism
Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition
Cargo-free particles divert neutrophil-platelet aggregates to reduce thromboinflammation
Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design
Bioactive lipid regulation of platelet function, hemostasis, and thrombosis
Fatty acids negatively regulate platelet function through formation of noncanonical 15-lipoxygenase-derived eicosanoids
Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions
The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation
Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder

The Holinstat Lab is accepting pre and postdoctoral applications. If interested, please email Dr. Holinstat (mholinst@med.umich.edu) with your resume/CV and a brief explanation as to why you would like to join our lab!